A 1 adenosine receptor agonists

Details A 1 adenosine receptor agonists A 1 adenosine receptor agonists

2007-09-18

2007-09-18

Tsang, Cecilia (Department: 1609)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S263100, C536S027300, C536S027600, C536S027620, C544S264000, C544S277000

Reexamination Certificate

active

11173416

ABSTRACT:
Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1adenosine receptor agonist having the structure of Formula I:wherein R is optionally substituted phenyl, that are useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.

REFERENCES:
patent: 6946449 (2005-09-01), Elzein et al.
patent: 7005425 (2006-02-01), Belardinelli et al.
patent: 7144871 (2006-12-01), Ibrahim et al.
patent: 2003/0216349 (2003-11-01), Belardinelli et al.
patent: 2004/0044225 (2004-03-01), Kanter et al.
patent: 2005/0020532 (2005-01-01), Elzein et al.
Robins,M.J. et al., “Nucleic acid related compounds. 66. Improved syntheses of 5′-chloro-5′-deoxy- and 5′-S-aryl(or alkyl)-5′-thionucleosides,” Canadian Journal of Chemistry, National Research Council, Ottawa, Canada, vol. 69, No. 9, 1991, pp. 1468-1474.
van Tilburg, et al, “‘N6,5’- Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3 Receptor”. J. Med. Chem. Division of Medicinal Chemlstw, Leiden/Amsterdam Center for Drug Research. The Netherlands; 1999. vol. 42. pp. 1393-1400.
Jaworski, J. S. “Nonequilibrium Solvent Polarization in Kinetics of SN2 Reactions,” International Journal of Chemical Kinetics, vol. 35, No. 2, 2003, pp. 61-66.
Van Tilburg et al, “N6,5'—Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3Receptor”,J. Med. Chem., Division of Medicinal Chemistry, Leiden/ Amsterdam Center for Drug Research, The Netherlands; 1999, vol. 42, pp. 1393-1400.
Robins M.J. et al., “Nucleic Acid Related Compounds. 66. Improved Syntheses of 5'-Chloro-5'-Thionucleosides”, Canadian Journal of Chemistry, National Research Council, Ottawa, Canada, vol. 69, No. 9, 1991, pp. 1468-1474.

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