9H-Dibenzo[b,f]imidazo[1,2-d][1,4]diazepines

Details 9H-Dibenzo[b,f]imidazo[1,2-d][1,4]diazepines 9H-Dibenzo[b,f]imidazo[1,2-d][1,4]diazepines

1974-10-02

1976-05-11

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239DD, 260268PC, 2602936, 260309, 424248, 424250, 424267, 424273, C07D48714

Patent

active

039562972

ABSTRACT:
9H-Dibenzoimidazodiazepine compounds of the formula: ##SPC1##
Wherein R.sub.1 is hydrogen, alkyl, ##SPC2##
In which W is H, chlorine, or fluorine, or R.sub.1 is ##EQU1## IN WHICH N IS AN INTEGER OF 2 TO 4, AND R.sub.o ' and R.sub.o ' are hydrogen or alkyl defined as above, or together ##EQU2## IS PYRROLIDINO, PIPERIDINO, N-methylpiperazino, or morpholino, wherein R.sub.3 and R.sub.4 are hydrogen or alkyl as defined above, or, R.sub.3 or R.sub.4 can be ##EQU3## IN WHICH ##EQU4## IS DEFINED AS ABOVE AND WHEREIN R.sub.2 and R.sub.6 are selected from the group consisting of hydrogen, halogen, or -CF.sub.3, are produced by multistep reactions.
The compounds of the formula above and the pharmacologically acceptable acid addition salts thereof are useful sedatives and anti-depressants. They can also be administered to mammals to alleviate anxieties and produce tranquilization and sedation.

REFERENCES:
patent: 3435042 (1969-03-01), Drukker et al.
patent: 3887575 (1975-06-01), Hester et al.

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