9A, 11-2C-bicyclic 9a-azalide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C536S007400

Reexamination Certificate

active

11324502

ABSTRACT:
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

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U.S. Appl. No. 11/008,581, filed Dec. 7, 2004, Or et al.
U.S. Appl. No. 11/236,043, filed Sep. 27, 2005, Or et al.
Bright, G. Michael, et al., “Synthesis, In Vitro and In Vivo Activity of Novel 9-Deoxo-9a-Aza-9a-Homoerythromycin A Derivatives; A New Class of Macrolide Antibiotics, the Azalides,”J. of Antibiotics, vol. XLI(8): 1029-1047 (1988).

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