99MTC(III) myocardial imaging agents that are effective in human

Details 99MTC(III) myocardial imaging agents that are effective in human 99MTC(III) myocardial imaging agents that are effective in human

1989-05-19

1990-04-17

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 14, A61K 4902, C07F 1300

Patent

active

049178792

ABSTRACT:
A myocardial imaging agent for humans is a technetium(III) complex ligated in the planar positions by a tetradentate ligand such as (acac).sub.2 en and in the axial positions by an ether containing phosphine ligand such as tris(3-methoxy-1-propyl)phosphine. The agent exhibits extremely rapid blood clearance after injection into a human and has a sufficiently high heart/liver and heart/lung ratios to provide effective myocardial images.

REFERENCES:
patent: 4758682 (1988-07-01), Collins et al.
patent: 4795626 (1989-01-01), Deutsch et al.
Deutsch et al., "Development of Non-Reducible Technetium 99m(III) Cations . . . ", J. Nucl. Medicine, 28: 1870-1880, 1987.
Kelly et al: J. Nucl. Med., vol. 30, No. 5, p. 773, May, 1989.
Lahiri et al: J. Nucl. Med. 1987, 28:721.
Kelly et al: J. Nucl. Med., vol. 30, No. 5, p. 773, May, 1989.
Lahiri et al: J. Nucl. Med. 1987, 28:721.

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