99MTC(III) myocardial imaging agents and method of use

Details 99MTC(III) myocardial imaging agents and method of use 99MTC(III) myocardial imaging agents and method of use

1990-12-21

1992-05-12

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 14, A61K 4902, C07F 1300

Patent

active

051125951

ABSTRACT:
A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans.

REFERENCES:
patent: 4795626 (1989-01-01), Deutsch et al.
patent: 4917879 (1990-04-01), Deutsch et al.
patent: 4957728 (1990-09-01), Deutsch et al.

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