99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi

Details 99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi 99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi

1990-05-11

1992-01-14

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

530388, 530390, A61K 4902, A61K 39395

Patent

active

050808834

ABSTRACT:
A diagnostic composition suitable for administration to a warm-blooded animal comprising a whole, fragmented, or recombinant MH-1 monoclonal antibody labeled with a Tc-99m triamide thiolate (N.sub.3 S) bifunctional chelate capable of intravenous injection into an animal to produce reliable visual imaging of thrombi.

REFERENCES:
patent: 4421735 (1983-12-01), Haber et al.
Rosebrough, S.F., et al., "Aged Venous Thrombi: Radioimmunoimaging with Fibrin-specific Monoclonal Antibody", Radiology 1987, 162, pp. 575-577.
Wasser, M.N.J.M., et al., "An In Vitro Model for the Scintigraphic Detection of Thrombi Using a 99m Tc.sup.m -Labeled Antifibrin Monoclonal Antibody", Nuclear Medicine Communications 1989, 10, pp. 653-659.
Koblik, P.D., et al., "Current Status of Immuno-Scintigraphy in the Detection of Thrombosis and Thromboembolism", Seminars in Nuclear Medicine 1989, vol. XIX, No. 3, pp. 221-237.
Knight, L. C., et al., "Evaluation of In-III Labeled Anti-Fibrin Antibody for Imaging Vascular Thrombi", Scientific Papers 1986, vol. 27, No. 6, p. 975.
Tymkewycz, P. M. et al., "Imaging of Human Thrombi in the Rabbit Jugular Vein: I: Comparison of Two Fibrin-Specific Monoclonal Antibodies", Thrombosis Research 1989, vol. 54, No. 5, pp. 411-421.
Pauwels, E. K. J., et al., "Imaging of Thrombi with Tc-99m Labeled Fibrin-Specific Monoclonal Antibody in a Rabbit Model", Scientific Papers 1986, vol. 27, No. 6, p. 975.

Affiliated with

Also associated with

Rating

99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 99 MTCN3S-Conjugated anti-bibrin monoclonal antibody as an in vi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-540037