9804 gene and methods of use thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352482, 4353201, 536 235, 935 1, 935 76, 935 77, 935 78, 935 22, 935 24, C12Q 168, C12N 500, C12N 1500, C07H 1700

Patent

active

054686121

ABSTRACT:
A substantially pure preparation of a 9804 DNA encoding a hematopoietic stem cell protein; antibodies to the 9804 gene product; methods of purifying 9804-expressing cells; and methods of screening for 9804 homologs are disclosed.

REFERENCES:
patent: 4946778 (1990-08-01), Ladner et al.
Sommer & Tautz, Nucleic Acids Research, vol. 17, No. 16, 1989, p. 6749.
Philbrick et al., Eur. J. Immunol. 1990. 20:87-92.
Baum, C. M., et al., "Isolation of a Candidate Human Hematopoietic Stem-Cell Population", 1992, Proc. Natl. Acad. Sci., vol. 89, pp. 2804-2808.
Chomczynski, P., et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chioroform Extraction", 1987, Analytical Biochem., vol. 162, pp. 156-159.
Cohen, J., "Naked DNA Points Way to Vaccines", 1993, Science, vol. 259, pp. 1691-1692.
Dumont, F. J., et al., "Interferon-.alpha./.beta. Enhances the Expression of Ly-6 Antigens on T Cells In Vivo and In Vitro", 1986, Eur. J. Immunol., vol. 16, pp. 735-740.
Dumont, F. J., et al., "Selective Up-Regulation by Interferon-.gamma. of Surface Molecules of the Ly-6 Complex in Resting T Cells: the Ly-6A/E and TAP Antigens are Preferentially Enhanced", 1987, Eur. J. Immunol., vol. 17, pp. 1183-1191.
Fleming, T. J., et al., "Characterization of Two Novel Ly-6 Genes", 1993, J. Immunol., vol. 150, pp. 5379-5390.
Gillis, S., et al., "T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity", 1978, J. Immunol., vol. 10, pp. 2027-2032.
Kohler, G., et al., "Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion", 1976, Eur. J. Immunol., vol. 6, pp. 511-519.
Kohler, G., et al., "Fusion Between Immunoglobulin-Secreting and Nonsecreting Myeloma Cell Lines", 1976, Eur. J. Immunol., vol. 6, pp. 292-295.
Kohler, G., et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", 1975, Nature, vol. 256, pp. 495-497.
Kozak, M. "At Least Six Nucleotides Preceding the AUG Initiator Codon Enhance Translation in Mammalian Cells", 1987, J. Mol. Biol., vol. 196, pp. 947-950.
Lin, A. Y., et al., "Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form", 1990, Science, vol. 249, pp. 677-679.
Philbrick, W. M., et al., "The CD59 Antigen is a Structural Homologue of Murine Ly-6 Antigens but Lacks Interferon Inducibility", 1990, Eur. J. Immunol., vol. 20, pp. 87-92.
Raz, E., et al., "Systemic Immunological Effects of Cytokine Genes Injected into Skeletal Muscle", 1993, Proc. Natl. Acad. Sci. USA, vol. 90, pp. 4523-4527.
Rock, K. L., et al., "The LY-6 Locus: A Multigene Family Encoding Phosphatidylinositol-Anchored Membrane Proteins Concerned with T-Cell Activation", 1989, No. 111, pp. 195-224.
Shevach, E. M., et al., "Ly-6: A Multigene Family in Search of a Function", 1989, Immunol. Today, vol. 10, pp. 195-200.
Spangrude, G. J., et al., "Purification and Characterization of Mouse Hematopoietic Stem Cells", 1988, Research Articles, vol. 241, pp. 58-62.
Spangrude, G. J., et al., "Mouse Hematopoietic Stem Cells", 1991, Blood, vol. 78, pp. 1395-1402.
Spangrude, G. J., et al., "Phenotypic Analysis of Mouse Hematopoietic Stem Cells Shows a Thy-1-Negative Subset", 1992, Blood, vol. 80, p. 1957-1964.
Stefanova, I., et al., "Characterization of a Broadly Expressed Human Leucocyte Surface Antigen Mem-43 Anchored in Membrane Through Phosphatidylinositol", 1989, Molec. Immunol., vol. 26, pp. 153-161.
Terstappen, L. W. M. M., et al., "Sequential Generations of Hematopoietic Colonies Derived From Single Nonlineage-Committed CD34.sup.+ CD38.sup.- Progenitor Cells", 1991, Blood, vol. 77, pp. 1218-1227.
Ulmer, J. B., et al., "Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein," 1993, Science, vol. 259, pp. 1745-1749.
Van De Rijn, M., et al., "Mouse Hematopoietic Stem-Cell Antigen Sca-1 is a Member of the Ly-6 Antigen Family", 1989, Proc. Natl. Acad. Sci. USA, vol. 86, pp. 4634-4638.
Williams, A. F., "Emergence of the Ly-6 Superfamily of GPI-Anchored Molecules", 1991, Cell Biol. Int'l., Reports, vol. 15, pp. 769-777.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

9804 gene and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 9804 gene and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 9804 gene and methods of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1136149

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.