Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-01-18
1996-10-15
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514263, 544269, A61K 31495, C07D47300, C07D47318
Patent
active
055654630
ABSTRACT:
The specification discloses the compounds of formula I ##STR1## wherein (a) --CH.sub.2 Ar represents ##STR2## in which R.sub.1 represents hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, benzyloxy, hydroxy or trifluoromethyl; and R.sub.2 represents hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, benzyloxy, hydroxy or trifluoromethyl; provided that R.sub.2 represents hydrogen or C.sub.1 -C.sub.3 -alkyl if R.sub.1 represents trifluoromethyl, or that R.sub.1 represents hydrogen or C.sub.1 -C.sub.3 -alkyl if R.sub.2 represents trifluoromethyl; or
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patent: 4772606 (1988-09-01), Sircar et al.
patent: 4923872 (1990-05-01), Kostlan et al.
"Purine Nucleoside Phosphorylase (PNP) Inhibitors: Potentially Selective Immunosuppressive Agents", by Sircar et al., Drugs of the Future, vol. 13, No. 7, 1988, pp. 653-668.
"8--amino--9--substituted guanines: Potent purine nucleoside phosphorylase (PNP) inhibitors", by Sircar et al., Agents and Actions, vol. 21, No. 3/4, 1987, pp. 253-256.
"A New Synthesis of Pyrrolo[3,2--d]pyrimidines(41 9--Deazapurines) via 3 --Amino--2--carboalkoxypyrroles," by Lim et al., J. Org. Chem., vol. 44, No. 22, 1979, pp. 3826-3829.
Ealick Steve
Erion Mark D.
Montgomery John A.
Secrist, III John A.
BioCryst Pharmaceuticals Inc.
Kunz Gary L.
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