9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivative

Details 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivative 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivative

1988-06-15

1989-06-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544282, 546283, 546292, 546297, 546314, 546315, 546346, 548248, 548253, 549 71, 549274, 549483, 560355, 560358, 570182, 260544R, 260544D, C07D47104, A61K 31505

Patent

active

048409537

ABSTRACT:
9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.

REFERENCES:
patent: 3960847 (1976-06-01), Yale
patent: 4022897 (1977-05-01), Yale
patent: 4122274 (1978-10-01), Juby
patent: 4209620 (1980-06-01), Juby
patent: 4457952 (1984-07-01), Juby

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