Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-28
1992-02-25
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544265, 544276, A61K 3152, C07D47300
Patent
active
050914324
ABSTRACT:
Novel bi-functional pharmaceutical compounds, particularly novel 9-substituted hypoxanthines of the general formula: ##STR1## where R is a neurologically active moiety, are described as pharmaceutical agents for treating neuroimmunologic disorders in mammals. Novel methods for the utilization of these compounds are also disclosed. These compounds exhibit uniquely dose-dependent, synergistic biological properties and are particularly useful for treating interrelated physiological systems.
REFERENCES:
patent: 3321369 (1967-05-01), Glasky et al.
patent: 3438968 (1969-04-01), Glasky
patent: 4221794 (1980-09-01), Simon et al.
patent: 4221909 (1980-09-01), Simon et al.
patent: 4221910 (1980-09-01), Giner-Sorolla
patent: 4728605 (1988-03-01), Fudenberg et al.
patent: 4952693 (1990-08-01), Sircan et al.
Chemical Abstracts--Registry File search of general structures (Annex 1).
Chemical Abstracts--Registry File search of publications related to structures located in Annex 1 search results (Annex 2).
Chemical Abstracts--Registry File search of 9H-Purine-9-propanoic acid derivatives with antiviral activities (Annex 3).
Chemical Abstracts--Registry File search of adenosine analogs (Annex 4).
Computer generated listing of Applicant's patents relating to memory enhancement, learning enhancement, and nucleic acids.
Computer generated listing of patents relating to Isoprinosine (Inosiplex).
Computer generated listing of immunomodulator patents assigned to Newport Pharmaceuticals.
American Chemical Society Chemical Abstracts Structural Search.
Kenneth A. Jacobson, "Chemical Approaches to the Definition of Adenosine Receptors", Adenosine Receptors, pp. 1-26, 1988.
Appel and McManaman, "Is a Breakdown of the Blood-Brain Barrier Cause or Effect?", Neurobiology of Aging, vol. 7, pp. 512-514, 1986.
MacDonald et al., "Immunological Parameters in the Aged and in Alzheimer's Disease", Clin. Exp. Immunol. (1982), vol. 49, pp. 123-128.
Miller et al., "Immunological Studies in Senile Dementia of the Alzheimer Type: Evidence for Enhanced Suppressor Cell Activity", Annals of Neurology, vol. 10, No. 6, pp. 506-510, Dec. 1981.
Stefansson et al., "Neuroimmunology of Aging", Clinical Neurology of Aging, pp. 76-94, 1984.
Weitkamp et al., "Alzheimer Disease: Evidence for Susceptibility Loci on Chromosomes 6 and 14", American Journal of Human Genetics, 35:443-453, 1983.
Ordy et al., "An Animal Model of Human-Type Memory Loss Based on Aging, Lesion, Forebrain Ischemia, and Drug Studies With the Rat", Neurobiology of Aging, vol. 9, pp. 667-683, 1988.
Ritzmann et al., "Blockage of Narcotic-Induced Dopamine Receptor Supersensitivity by Cyclo (Leu-Gly)", Proc. Natl. Acad. Sci. USA, vol. 76, No. 11, pp. 5997-5998, Nov. 1979.
Tsang et al., "Modulaton of T- and B-Lymphocyte Functions by Isoprinosine in Homosexual Subjects with Prodromata and in Patients with Acquired Immune Deficiency Syndrome (AIDS)", Journal of Clinical Immunology, vol. 4, No. 6, pp. 469-478, 1984.
Hadden et al., "Levamisole and Inosiplex: Antiviral Agents with Immunopotentiating Action", Annals of the New York Academy of Sciences, vol. 284, pp. 139-152, 1977.
Olsson et al., "N.sup.6 -Substituted N-Alkyladenosine-5'-Uronamides: Bifunctional Ligands Having Recognition Groups for A1 and A2 Adenosine Receptors", J. Med. Chem. 1986, vol. 29, pp. 1683-1689.
Collis et al., "Evidence That the Intracellular Effects of Adenosine in the Guinea-Pig Aorta Are Mediated by Inosine", European Journal of Pharmacology, vol. 121, pp. 141-145, 1986.
Jacobson et al., "A Functionalized Congener Approach to Agonists and Antagonists for Adenosine Receptors", Adenosine & Adenine Nucleotides: Physiology and Pharmacology, 1988, pp. 27-38.
Daly et al., "7-Deaza-9-Phenyladenines: A New Class of Adenosine Receptor Antagonists", Biochemical Pharmacology, vol. 37, No. 19, pp. 3749-3753, 1988.
Arthur D. Broom, "Rational Design of Enzyme Inhibitors: Multisubstrate Analogue Inhibitors", American Chemical Society, 1988.
Jacob et al., "Synthesis, Brain Uptake, and Pharmacological Properties of a Glyceryl Lipid Containing GABA and the GABA-T Inhibitor .gamma.-Vinyl-GABA", J. Med. Chem., vol. 33, pp. 733-736, 1990.
Hardy et al., "An Integrative Hypothesis Concerning the Pathogenesis and Progression of Alzheimer's Disease", Neurobiology of Aging, vol. 7, pp. 489-502, 1986.
Singh and Fudenberg, "Implications of Immunomodulant Therapy in Alzheimer's Disease", Progress in Drug Research, vol. 32, pp. 21-42, 1988.
Glasky and Gordon, "Inosiplex Treatment of Acquired Immuno-Deficiencies: A Clinical Model for Effective Immunomodulation", Meth and Find Clin Pharmacol 1986, 8(1):35-40.
Burnett et al., "Dialkylaminoalkanol Esters of p-Aminobenzoic Acid", J. Am. Chem. Soc., vol. 59, pp. 2248-2252, 1937.
Grumbling Matthew V.
Shah Mukund J.
LandOfFree
9-substituted hypoxanthine bi-functional compounds and their neu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 9-substituted hypoxanthine bi-functional compounds and their neu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 9-substituted hypoxanthine bi-functional compounds and their neu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1893454