9-Substituted carbacyclin analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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260404, 2604045, 260408, 260410, 2604105, 2604109R, 260413, 260464, 260465D, 260465F, 564152, 564158, 564159, 564172, 564188, 564428, 564454, 564427, 564455, 564466, 564501, 564 87, 564 88, 564 89, 564 91, 564 96, 564 97, 564 98, 564 99, 560 12, 560 39, 560 45, 560 56, 560119, 562466, 562455, 562444, 562427, 424263, 424275, 424285, 424305, 424308, 424317, 424320, 424321, 424324, 424325, 424330, 424343, 568633, 568734, 568819, 542421, 542429, 549 79, 549501, C07C17700, C07C 5726

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active

044905556

ABSTRACT:
Novel compounds of the following general formula: ##STR1##

REFERENCES:
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patent: 4306075 (1981-12-01), Aristoff
patent: 4306076 (1981-12-01), Nelson
Aristoff, P. A., J. Org. Chem. 46 (No. 9), 1981, pp. 1954-1957, "Practical Synthesis of 6a-Carbaprostaglandin I.sub.2 ".
Barco, A., et al., J. Org. Chem. 45 (No. 23), 1980, pp. 4776-4778 "A New, Elegant Route to a Key Intermediate for the Synthesis of 9(O)-Methanoprostacyclin".
Hayashi, M., et al., Chem. Lett. 1979, pp. 1437-1440 "A Synthesis of 9(O)-Methanoprostacyclin".
Kojima, K., et al., Tetrahedron Lett. 39, 1978, pp. 3743-3746 "Total Synthesis of 9(O)-Methanoprostacyclin and Its Isomers".
Morton, D. R., Jr., et al., J. Org. Chem. 44 (No. 16), 1979, pp. 2880-2887 "Total Synthesis of 6a-Carbaprostaglandin I.sub.2 and Related Isomers".
Nicolaou, K. C., et al., J.C.S. Chem. Comm., 1978, pp. 1067-1068 "Total Synthesis of Carboprostacyclin, a Stable and Biologically Active Analogue of Prostacyclin(PGI.sub.2)".
Shibasaki, M., et al., Chem. Lett. 1979, pp. 1299-1300 "A Stereo and Regiospecific Route to the Synthetic Intermediate for the Synthesis of 9(O)-Methanoprostacyclin".
Shibasaki, M., et al., Tetrahedron Lett. 5, 1979, pp. 433-436 "New Synthetic Routes to 9(O)-Methanoprostacyclin. A Highly Stable and Biologically Potent Analog of Prostacyclin".
Skuballa, W., et al., Angew. Chem. 93 (No. 12), 1981, pp. 1080-1081, "Ein neuer Weg zu 6a-Carbacyclin--Synthese eines stabilen, biologisch potenten Prostacyclin-Analogons".
Sugie, A., et al., Tetrahedron Lett. 28, 1979, pp. 2607-2610 "Stereocontrolled Approaches to 9(O)-Methanoprostacyclin".
Yamazaki, M., et al., Chem. Lett. 1981, pp. 1245-1248 "1,2-Carbonyl Transposition of cis-Bicyclo[3.3.0]octan-2-one to Its 3-one Skeleton: Application to Syntheses of dl-Hirsutic Acid and dl-9(O)-Methanoprostacyclin".

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