9-Substituted carbacyclin analogs

Details 9-Substituted carbacyclin analogs 9-Substituted carbacyclin analogs

1984-09-27

1986-04-29

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

549422, C07C17700

Patent

active

045858861

ABSTRACT:
Novel compounds of the following general formula: ##STR1##

REFERENCES:
patent: 4180657 (1979-12-01), Sih
patent: 4192891 (1980-03-01), Haslanger
patent: 4225508 (1980-09-01), Sih
patent: 4238414 (1980-12-01), Morton, Jr.
patent: 4306075 (1981-12-01), Aristoff
patent: 4306076 (1981-12-01), Nelson
Aristoff, P. A., J. Org. Chem. 46 (No. 9), 1981, pp. 1954-1957, "Practical Synthesis of 6a-Carbaprostaglandin I.sub.2 ".
Barco, A. et al., J. Org. Chem. 45 (No. 23), 1980, pp. 4776-4778, "A New, Elegant Route to a Key Intermediate for the Synthesis of 9(0)-Methanoprostacyclin".
Hayashi, M. et al., Chem. Lett. 1979, pp. 1437-1440, "A Synthesis of 9(0)-Methanoprostacyclin".
Kojima, K. et al., Tetrahedron Lett. 39, 1978, pp. 3743-3746, "Total Synthesis of 9(0)-Methanoprostacyclin and Its Isomers".
Morton, D. R., Jr., et al., Org. Chem. 44 (No. 16), 1979, pp. 2880-2887, "Total Synthesis of 6a-Carbaprostaglandin I.sub.2 and Related Isomers".
Nicolaou, K. C. et al., J.C.S. Chem. Comm., 1978, pp. 1067-1068, "Total Synthesis of Carboprostacyclin, a Stable and Biologically Active Analogue of Prostacyclin (PGI.sub.2)".
Shibasaki, M. et al., Chem. Lett. 1979, pp. 1299-1300, "A Stereo and Regiospecific Route to the Synthetic Intermediate for the Synthesis of 9(0)-Methanoprostacyclin".
Skuballa, W. et al., Agnew. Chem. 93 (No. 12), 1981, pp. 1080-1081, "Ein neuer Weg zu 6a-Carbacyclinen--Synthese eines stabilen, biologisch potenten Prostacyclin-Analogons".
Shibasaki, M. et al., Tetrahedron Lett. 5, 1979, pp. 433-436, "New Synthetic Routes to 9(0)-Methanoprostacyclin. A Highly Stable and Biologically Potent Analog of Prostacyclin".
Sugie, A. et al., Tetrahedron Lett. 28, 1979, pp. 2607-2610, "Stereocontrolled Approaches to 9(0)-Methanoprostacyclin".
Yamazaki, M. et al., Chem. Lett. 1981, pp. 1245-1248, "1,2-Carbonyl Transposition of cis-Bicyclo[3.3.0]octan-2-one to Its 3-one Skeleton: Application to Syntheses of dl-Hirsutic Acid and dl-9-(0)-Methanoprostacyclin".
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