Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-16
2006-05-16
Wilson, James O. (Department: 1623)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S086000, C436S504000, C436S545000, C436S546000, C436S547000, C514S045000, C514S047000, C514S048000, C536S026500, C536S026700, C544S264000
Reexamination Certificate
active
07045309
ABSTRACT:
The present invention relates to 9-substituted adenine derivatives represented by formula (I)wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected from the group consisting of O, S, N(H), CH2, CH and C; Y is selected from the group consisting of H, hydroxy, C1-4alkyl, C1-4alkoxy and halogen; R is selected from the group consisting of H, hydroxymethyl, C1-4alkyl, and C1-4alkoxy; R1is selected from the group consisting of O, NH and CH2; R2represents a radical selected from the group consisting of —(CH2)n—S—C(O)—R4and —(CH2)n—S—S—R4, where n=1-4 and R4is a C1-4-alkyl or aryl group and R4is optionally substituted with a halogen, amino, N-alkylamino, N, N-dialkylamino or C1-4alkoxy group and wherein each of the R2radicals may be the same or different; and R3is O or S. The derivatives are useful as prodrugs for inhibiting adenylyl cyclase and lowering 3′:5′-cAMP in cells, thereby inhibiting adenylyl cyclase dependent effects within cells.
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Gosselin Gilles
Johnson Roger A.
Laux Wolfgang
Pande Praveen
Crane L. E.
Darby & Darby
The Research Foundation of State University of New York
Wilson James O.
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