9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors

Details 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors

1992-02-03

1993-08-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142342, 514253, 514254, 544117, 544238, 544280, A61K 31505, C07D47104

Patent

active

052369269

ABSTRACT:
The present invention is novel 9-substituted-8-hydroxy or -8-halo-9 deazaguanines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.

REFERENCES:
patent: 4923872 (1990-05-01), Kostlan et al.
patent: 4985433 (1991-01-01), Secrist III et al.
patent: 4985434 (1991-01-01), Secrist III et al.
patent: 5008265 (1991-04-01), Secrist et al.
patent: 5008270 (1991-04-01), Secrist et al.
CA 113(23): 204453m (1990).

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