9-purinyl phosphonic acid derivitives for treating gout

Details 9-purinyl phosphonic acid derivitives for treating gout 9-purinyl phosphonic acid derivitives for treating gout

1995-06-06

1996-02-27

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514258, 514260, 514262, 514265, A61K 3152

Patent

active

054949122

ABSTRACT:
This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.

REFERENCES:
patent: 4927830 (1990-05-01), Townsend et al.
patent: 4988680 (1991-02-01), Halazy et al.
patent: 5102879 (1992-04-01), Kostlan et al.
Chemical Abstracts, vol. 106, p. 771, 1987, 106:176792f, abstracting Davisson, V. J., et al., related to the "Synthesis of nucleotide 5'-diphosphates from 5'-O-tosyl nucleosides," J. Org. Chem. 52(9), 1794-1801, 1987.
Nakamura, C. E., et al, Biochemical Pharmacology, vol. 35, No. 2, pp. 133-136, 1986.
Stoeckler, J. D., et al., Federation Proceedings, vol. 25, No. 12, pp. 2773-2778, 1986.
Daddona, P. E., et al., The Journal of Biological Chemistry, vol. 261, No. 25, pp. 11667-11673, 1986.
Suzuki, et al., Biochemical and Biophysical Research Communications, vol. 156(3):1144-1151 (Nov. 16, 1988).
Back, et al., Br. J. Clin. Pharmac. 33:319-322 (1992).
Stoeckler, J. D., et al., Biochemistry 19, 102-107 (1980).
Cooney, D. A., et al., Biochemical Pharmacology 36(11), 1765-1768 (1987).
Pauwels, R., et al., Bioch. Pharm. 37(7), 1317-1325 (1988).
Baba, M., et al., Biochem. Biophys. Res. Comm. 145(3), 1080-1086 (1987).
Sanghvi, Y. S., et al., J. Med. Chem 21, 330-335 (1988).
Ahluwalia, G., et al., Biochem. Pharmacology 36(22), 3797-3800 (1987).
Stein, J. M., et al, Biochemical Pharmacology, vol. 36, No. 8, pp. 1237-1244, 1987.
Prisbe, E. J., et al., J. Med. Chem. 29, 671-675, 1986.

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