9-purinyl phosphonic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 81, 514261, 514262, 514885, 544264, 544265, 544266, 544267, A61K 3152, C07D40304

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active

055389783

ABSTRACT:
This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immuno-suppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.

REFERENCES:
patent: 4927830 (1990-05-01), Townsend et al.
patent: 4988680 (1991-01-01), Halazy et al.
patent: 4988702 (1991-01-01), Kostlan et al.
Suzuki, et al., Biochemical and Biophysical Research Communications, vol. 156(3):1144-1151 (Nov. 16, 1988).
Back, et al., Br. J. Clin. Pharmac. 33:319-322 (1992).
Stoeckler, J. D., et al., "Human Erytrhocytic Purine Nucleoside Phosophorylase: Reaction With Sugar-Modified Nucleoside Substrates", Biochemistry 19, 102-107 (1980).
Cooney, D. A., et al., "Initial Studies On The Cellular Pharmacology of 2',3'-dideoxyadenosine, An Inhibitor of HTLV-III Infectivity", Biochemical Pharmacology 36(11), 1765-1768 (1987).
Pauwels, R., et al., "Investigations on the Anit-HIV activity of 2',3'-dideoxyadenosine analogues with Modifications In Either The Pentose Or Purine Moiety", Bioch. Pharm. 37(7), 1317-1325 (1988).
Baba, M., et al., "Selective Inhibition Of Human Immunodeficiency Virus (HIV) By 3'-Azido-2'3'-Dideoxyguanosine In Vitro", Biochem. Biophys. Res. Comm. 145(3), 1080-1086 (1987).
Sangvhi, Y. S., et al., "Synthesis and Evaluation of 5-Amino-1-.alpha.-D-ribofuranosyl-1,2,4-trizole-3-carobxamide and Certain Related Nucleosides as Inhibitors of Purine Nucleoside Phosphorylase", J. Med. Chem 21, 330-335 (1988).
Ahluwalia, G., et al., "Initial Studies On The Cellular Pharmacology of 2',3'-Dideoxyinosine, An Inhibitor of HIV Infectivity", Biochem. Pharmacology 36(22), 3797-3800 (1987).
Chemical Abstracts, vol. 106, p. 771, 1987, 106:176792f, abstracting Davisson, V. J., et al., relates to the "Synthesis of nucleotide 5'-diphosphates from 5'-O-tosyl nucleotides," J. Org. Chem. 52(9), 1794-801, 1987.
Stein, J. M., et al., "Inhibition of human purine nucleoside phosphorylase by acyclic nucleosides and nucleotides," Biochemical Pharmacology, vol. 36, No. 8, pp. 1237-1244, 1987.
Prisbe, E. J., et al., "Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-porpoxy)methyl]guanine," J. Med. Chem. 29, 671-675, 1987.
Nakamura, C. E., et al., "Inhibition of purine nucleoside phosphorylase by 9-(phosphonoalkyl)hypoxanthines," Biochemical Pharmacology, vol. 35, No. 2, pp. 133-136, 1986.
Stoeckler, J. D., et al., "Design of purine nucleoside phosphorylase inhibitors," Federation Proceedings, vol. 25, No. 12, pp. 2773-2778, 1986.
Daddona, P. E., et al., "Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erthyrocyte culture", The Journal of Biological Chemistry, vol. 261, No. 25, pp. 11667-11673, 1986.
Halazy et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 5, pp. 407-410, (1992).
Kelley et al., J. Med. Chem., vol. 36, No. 22, pp. 3455-3463 (1993).
Erion et al., J. Med. Chem., vol. 37, p. 1034 (1994).
Weibel et al., Biochemical Pharmacology, vol. 48, No. 2, pp. 245-252 (1994) .

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