9-(phosponylmethoxyalkyl) adenines, the method of preparation an

Details 9-(phosponylmethoxyalkyl) adenines, the method of preparation an 9-(phosponylmethoxyalkyl) adenines, the method of preparation an

1986-04-25

1989-02-28

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544277, C07D 965, C07D47334

Patent

active

048087165

ABSTRACT:
The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R.sup.2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyran-2-yloxyethylene, (1-ethoxyethoxy)ethylene or 1,2-O-isopropylidene-1,2-dihydroxypropylene group the method of their preparation and utilization.
Compounds of the general formula I exhibit biological effects (e.g. antiviral) or can be converted into compounds with such effects.

REFERENCES:
patent: 4323573 (1982-04-01), Schaeffer
patent: 4659825 (1987-04-01), Holy et al.
Holy, et al., Collection Czechoslovak Chem. Commun., vol. 47, pp. 3447-3463, (1982).
Benes, et al., Chemical Abstracts, vol. 104, 220678h, (1986).

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