9-Oxo-11.alpha.-methyl-15.EPSILON.-hyroxyprost-13(trans)-enoic a

Details 9-Oxo-11.alpha.-methyl-15.EPSILON.-hyroxyprost-13(trans)-enoic a 9-Oxo-11.alpha.-methyl-15.EPSILON.-hyroxyprost-13(trans)-enoic a

1975-05-05

1976-12-07

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603109, 2603433R, 2604109R, 260413, 260468K, 260514K, 260514D, 424305, 424317, C07C17700

Patent

active

039962636

ABSTRACT:
Prostanoic acid derivatives having the formula ##STR1## wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from one to 5 carbon atoms, R.sup.2 and R.sup.3 may be the same or different and each represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and R.sup.4 represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.
The compounds are useful as anti-ulcerogenic agents and may be prepared by reducing a compound having the formula ##STR2## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same above and Z represents a carbonyl-protecting group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Z are the same as above and removing the carbonyl-protecting group from the latter compound.

REFERENCES:
patent: 3849474 (1974-11-01), Abraham et al.
patent: 3899525 (1975-08-01), Oda et al.
B491,711, Mar. 1976, Kao et al., 260/240 R.

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