9-N-ethenyl derivatives of 9(S)-erythromycylamine

Details 9-N-ethenyl derivatives of 9(S)-erythromycylamine 9-N-ethenyl derivatives of 9(S)-erythromycylamine

1997-10-23

1998-12-29

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 72, 536 74, 536 75, 549415, A61K 3170, C07H 1708, C07G 1100, C07D31500

Patent

active

058542191

ABSTRACT:
The invention relates to 9-N-ethenyl derivatives of 9 (S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent nitryl, a carboxyl group of the formula COOR.sup.3, wherein R.sup.3 represents a C.sub.1 -C.sub.4 alkyl group, or a keto group of the formula COR.sup.4, wherein R.sup.4 represents a C.sub.1 -C.sub.4 alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.

REFERENCES:
patent: 3794635 (1974-02-01), Evans

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