9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefo

Details 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefo 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefo

1979-05-29

1981-04-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

4242484, 42424855, 42424856, 42424857, 42424858, 424250, 424258, 544126, 544361, 546 15, 546101, 546110, 546156, C07D21502, C07D22106, A61K 3147

Patent

active

042607647

ABSTRACT:
1,9-Dihydroxyoctahydrobenzo[c]quinolines (I), 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones (II), and 1-hydroxy-tetrahydrobenzo[c]quinolines (IV) useful as CNS agents, especially as analgesics and tranquilizers, as hypotensives, as agents for the treatment of glaucoma and as diuretics; intermediates therefor (III) and derivatives thereof having the formulae ##STR1## wherein R is hydroxy, alkanoyloxy having from one to five carbon atoms and hydroxymethyl;

REFERENCES:
patent: 3506654 (1970-04-01), Fried
patent: 3976651 (1976-08-01), Gerster et al.
patent: 3978064 (1976-08-01), Johnson et al.
patent: 4013662 (1977-03-01), Harbert
A. Daruwala et al., Chem. Abstracts 82: 25660w (1975) Synthesis and Some Biological Activities in Mice of 3,3-dialkyl-1,2,3,4-tetrahydro-4-quinolinones.

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