9-Hydroxydibenzo[b,d]pyrans and intermediates

Details 9-Hydroxydibenzo[b,d]pyrans and intermediates 9-Hydroxydibenzo[b,d]pyrans and intermediates

1977-07-27

1979-03-06

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424263, 424274, 424284, 544150, 2603265CA, 26032634, 546196, 546269, 546187, 2603453, 546194, 544364, 544375, A61K 3135, C07D49312

Patent

active

041431391

ABSTRACT:
9-Hydroxydibenzo[b,d]pyrans useful as analgesics, hypotensives, immunosuppressants, tranquilizers; as anti-secretory and anti-anxiety drugs; intermediates therefor and derivatives thereof having the formulae ##STR1## wherein R is hydrogen or alkanoyl having from one to five carbon atoms; R.sub.1 is hydrogen, alkanoyl having from one to five carbon atoms or --CO--(CH.sub.2).sub.P --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4; each of R.sub.2 and R.sub.3 when taken individually is hydrogen or alkyl having from one to four carbon atoms; R.sub.2 and R.sub.3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrrolo, pyrrolidino, morpholino and N-alkylpiperazino having from one to four carbon atoms in the alkyl group;
Each of R.sub.4 and R.sub.5 is hydrogen, methyl or ethyl;
R.sub.0 is oxo or alkylenedioxy having from two to four carbon atoms;
Z is

REFERENCES:
patent: 3901926 (1975-08-01), Winn et al.
patent: 3929835 (1975-12-01), Winn et al.
patent: 3968125 (1976-07-01), Archer

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