Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-06-13
2000-06-13
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546106, 546 93, 546 79, C07D21910, C07D21912, C07D22106
Patent
active
060751444
ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein n is 1-4; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.2 or --NR.sub.3 R.sub.4 where R.sub.2 is hydrogen or loweralkyl, and R.sub.3 and R.sub.4 are independently hydrogen, loweralkyl or cycloalkyl; R is hydrogen, loweralkyl or loweralkylcarbonyl; and R.sub.1 is hydrogen, loweralkyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, furylloweralkyl, thienylloweralkyl, pyridinylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof which are useful for enhancing memory.
REFERENCES:
patent: 4816456 (1989-03-01), Summers
patent: 4868177 (1989-09-01), Shutske et al.
patent: 5336485 (1994-08-01), Fariss
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Hendrickson et al. Jour. Chromatog. vol. 487 No. 2 pp. 401-408 (1989).
Hendrickson et al. Chem. Abstr. vol. 110 entry 185270u (1989).
Shutske et al. Chem. Abstr vol. 110 entry 95025p (1988) Abstracting Europe 288852.
Burger, Medicinal Chemistry, 3rd Ed, Part I, Wiley-Interscience, NY, 1970, p. 53.
Kapples Kevin James
Shutske Gregory Michael
Ford John M.
Hoechst Marion Roussel Inc.
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