9-fluoroprostaglandin derivatives, their preparation and use as

Details 9-fluoroprostaglandin derivatives, their preparation and use as 9-fluoroprostaglandin derivatives, their preparation and use as

1987-01-20

1988-12-06

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 514573, 514601, 514616, 514729, 560 62, 560121, 562472, 562503, 561 98, 561152, 568838, C07C17700, A61K 31557

Patent

active

047896850

ABSTRACT:
9-fluoroprostane derivatives of Formula I ##STR1## wherein R.sub.1 is CH.sub.2 OH or ##STR2## wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R.sub.1 is the residue ##STR3## wherein R.sub.3 is an acid residue or R.sub.2 and A is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH--,

REFERENCES:
Muchowski Chemistry, Biochemistry and Pharmacological Activity of Prostanoids, p. 51, (1978).
Nicolau et al., Prostaglandins, 31(4), p. 811 (1986).

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