9-Epi-mitomycin B and D compounds

Details 9-Epi-mitomycin B and D compounds 9-Epi-mitomycin B and D compounds

1981-11-23

1983-07-26

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424274, A61K 3140, C07D48704

Patent

active

043955584

ABSTRACT:
Mitomycin compounds of the general formula (I): ##STR1## wherein X is selected from an alkoxy group having 1 to 4 carbon atoms and amino group; and Z is selected from --OH, --OCONH.sub.2 and --OCO.sub.2 C.sub.6 H.sub.5 groups. The compounds of this formula may be used as starting materials for the preparation of various mitomycin compounds. When X is as hereinbefore defined and Z is --OCONH.sub.2, the compounds exhibit antibacterial activity and are of potential interest as medicaments. Preferred examples of the compounds are 9-Epi-mitomycin B and 9-epi-mitomycin D. The compounds of the formula (I) may be obtained from known mitomycin B or mitomycin D.

REFERENCES:
patent: 3738998 (1973-06-01), Uzu et al.
patent: 4264504 (1981-04-01), Urakawa et al.

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