9-Desoxoerythromycin compounds as prokinetic agents

Details 9-Desoxoerythromycin compounds as prokinetic agents 9-Desoxoerythromycin compounds as prokinetic agents

2007-05-01

2007-05-01

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007200

Reexamination Certificate

active

11016529

ABSTRACT:
9-Desoxoerythromycin compounds of formula Iwherein R1, R2, R3, R4, and R5are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.

REFERENCES:
patent: 4382085 (1983-05-01), Sciavolino et al.
patent: 4382086 (1983-05-01), Sciavolino et al.
patent: 4857641 (1989-08-01), Hauske
patent: 5008249 (1991-04-01), Omura et al.
patent: 5175150 (1992-12-01), Omura et al.
patent: 5470961 (1995-11-01), Harada et al.
patent: 5523401 (1996-06-01), Freiberg et al.
patent: 5523418 (1996-06-01), Freiberg et al.
patent: 5538961 (1996-07-01), Freiberg et al.
patent: 5554605 (1996-09-01), Freiberg et al.
patent: 5578579 (1996-11-01), Lartey et al.
patent: 5654411 (1997-08-01), Lartey et al.
patent: 5658888 (1997-08-01), Koga et al.
patent: 5712253 (1998-01-01), Lartey et al.
patent: 5834438 (1998-11-01), Lartey et al.
patent: 5922849 (1999-07-01), Premchandran et al.
patent: 5959088 (1999-09-01), Miura et al.
patent: 6084079 (2000-07-01), Keyes et al.
patent: 6169168 (2001-01-01), Asaka et al.
patent: 6492562 (2002-12-01), Ashley et al.
patent: 6514944 (2003-02-01), Chu et al.
patent: 6667338 (2003-12-01), Ma et al.
patent: 6762168 (2004-07-01), Chu et al.
patent: 6946482 (2005-09-01), Santi et al.
patent: 2002/0025936 (2002-02-01), Ashley et al.
patent: 2002/0094962 (2002-07-01), Ashley et al.
patent: 2002/0132782 (2002-09-01), Ma et al.
patent: 2002/0156028 (2002-10-01), Chu et al.
patent: 2002/0192709 (2002-12-01), Carreras et al.
patent: 2004/0138150 (2004-07-01), Santi et al.
patent: 60-218321 (1985-11-01), None
U.S. Appl. No. 10/926,170, filed Aug. 24, 2004, Carreras et al.
Carreras et al.,Anal. Biochemistry, 300, 146-151 (2002), “Stable Expression of a Synthetic Gene for Human Motilin Receptor: Use in an Aequorin-Based Receptor Activation Assay”.
Chemical Abstracts No. 104:82047 (abstract of JP 60-218321).
Depoortere et al.,J. Gastrointestinal Motility, 1, 150-159 (1989), “Structure-Activity Relation of Erthromycin-Related Macrolides in Inducing Contractions and in Displacing Bound Motilin in Rabbit Duodenum”.
Desai et al.,Biotechnol. Prog. 20, 1660-1665 (2000), “Improved Bioconversion of 15-Fluoro-6-deoxyerythro-nolide B to 15-Fluoroerythromycin A by Overexpression of the eryK Gene inSaccharopolyspora erythraea”.
Faghih et al.,Biorg. &Med. Chem. Lett., 8 (1998), 805-810, “Preparation of 9-Deoxo-4″-deoxy-6,9-epoxyerythromycin Lactams ‘Motilactides’: Potent and Orally Active Prokinetic Agents”.
Faghih et al.,Drugs of the Future, 23 (8), 861-872 (1998), “Motilides and motilactides: design and development of motilin receptor agonists as a new class of gastrointestinal prokinetic drugs”.
Faghih et al.,J. Antibiotics, 43 (10), 1334-1336 (1990), “Synthesis and Antibacterial Activity of (9S)-9-Dihydroclarithromycin”.
Faghih et al.,J. Med. Chem., 1998, 41, 3402-3408, “Synthesis of 9-Deoxo-4″-deoxy-6,9-epoxyerythromycin Derivatives: Novel and Acid-Stable Motilides”.
Faghih et al.,Synlett751 (Jul. 1998), “Entry into Erythromycin Lactams: Synthesis of Erythromycin A Lactam Enol Ether as a Potential Gastrointestinal Prokinetic Agent”.
Hauske et al.,J. Org. Chem. 49, 712-714 (1984), “Regiospecific Synthesis of 9-Desoxo Erythromycin A”.
Ku et al.,J. Antibiotics52 (10), 908-912 (1999), “Synthesis and Antibacterial Activities of Novel 12-O-Methylerythromycin A Derivatives”.
Ku et al.,J. Org. Chem. 64, 2107-2109 (1999), Synthe-sis of a Novel Macrolide: 9(S)-9-Dihydro-12-O-Methyl-erythromycin A via Regioselective Methylation.
Lartey et al.,J. Med. Chem., 38, 1793-1798 (1995), “Synthesis of 4″-Deoxy Motlildes: Identification of a Potent and Orally Active Prokinetic Drug Candidate”.
Omura et al.,J. Antibiotics(1985), 38, 1631-2, “Gastroin-testinal Motor-Stimulating Activity of Macrolide Antibiotics and the Structure-Activity Relationship”.
Stanat et al.,Mol. Cellular Biochem., 254, 1-7 (2003), “Characterization of the Inhibitory Effects of Erythromycin and Clarithromycin on the HERG Potassium Channel”.
Stresser et al.,Drug Metabolism Disposition, 30 (7), 845-52 (2002), “Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4”.
Wermuth, “Designing Prodrugs and Bioprecursors,” in Wermuth, ed.,The Practice of Medicinal Chemistry, 2nd Ed., pp. 561-586 (Academic Press 2003).

Affiliated with

Also associated with

Rating

9-Desoxoerythromycin compounds as prokinetic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 9-Desoxoerythromycin compounds as prokinetic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 9-Desoxoerythromycin compounds as prokinetic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3823580