9-Deoxy-9-methylene-PGF-type lactones

Details 9-Deoxy-9-methylene-PGF-type lactones 9-Deoxy-9-methylene-PGF-type lactones

1977-09-12

1979-03-13

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

542413, 542429, C07D31300

Patent

active

041442539

ABSTRACT:
This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 4032543 (1977-06-01), Bundy
patent: 4045449 (1977-08-01), Bundy

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