9-Deoxy-9-methylene-PGF-type amides

Details 9-Deoxy-9-methylene-PGF-type amides 9-Deoxy-9-methylene-PGF-type amides

1977-04-11

1978-07-04

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BF, 260290H, 26029373, 2603264, 260556A, 260556AC, 260557R, 260559R, 542426, 542429, 560 61, 560 62, 560219, 560220, 424320, 424324, 544172, 544174, 544173, 544391, C07C10319, C07C10326, A61K 3116, A61K 31165

Patent

active

040988058

ABSTRACT:
The present invention relates in part to novel amido, cycloamido, carbonylamido and sulfonylamido derivatives and p-substituted phenyl esters of 9-deoxy-9-methylene-PGF-type compounds. These novel amides produce surprisingly prolonged oral activity as pharmacological agents, as compared to the previously known 9-deoxy-9-methylene-PGF-type compounds.
Further, the novel p-substituted phenyl esters provide more stable pharmaceutical formulations as compared to known 9-deoxy-9-methylene-PGF-type esters.
Additionally, a novel series of 16-phenyl-9-deoxy-9-methylene-PGF-type compounds in free acid, ester, C-1 alcohol, and C-1 amine form is provided. Such compounds exhibit characteristic prostaglandin-type pharmacological actions.

REFERENCES:
patent: 3890372 (1975-06-01), Morozowich
patent: 3927197 (1975-12-01), Monkhouse
patent: 3954741 (1976-05-01), Schaaf et al.
patent: 3981868 (1976-09-01), Bernady et al.
patent: 4060534 (1977-11-01), Bundy

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