9-Deoxy-9-methylene-PGE compounds

Details 9-Deoxy-9-methylene-PGE compounds 9-Deoxy-9-methylene-PGE compounds

1977-09-12

1984-07-24

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C17700

Patent

active

044619170

ABSTRACT:
This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 4060534 (1977-11-01), Bundy
Samuelsson et al, Advances in Prostaglandin and Thromboxane Research, vol. 1 (1976) 488-491.

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