9-Deoxy-9-methylene derivatives of (dl)-16-phenoxy and 16-phenox

Details 9-Deoxy-9-methylene derivatives of (dl)-16-phenoxy and 16-phenox 9-Deoxy-9-methylene derivatives of (dl)-16-phenoxy and 16-phenox

1982-03-22

1983-11-29

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 61, 560 62, 562465, 562471, 562472, 568435, 568442, 568630, 568656, 424308, 424317, 424333, 424340, 2605011, 26050113, C07C17700

Patent

active

044182066

ABSTRACT:
Novel compounds of the formula: ##STR1## wherein A is CHOH, CHO or COOR; R is hydrogen or a lower alkyl group of 1 to 4 carbon atoms; and the pharmaceutically acceptable, non-toxic salts of compounds in which R is hydrogen; and X is hydrogen, o-, m- or p-halo(fluoro, chloro or bromo), o-, m- or p-methyl or o-, m- or p-methoxy. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as inhibitors of gastric acid secretions and as agents for the control of asthmatic attack, because of their bronchodilating activity.

REFERENCES:
Derwent Abstract 81074x/43, U.S. Pat. No. 3,985,791, 23.06.75.
Derwent Abstract 92730b/51, U.S. Pat. No. 4,178,457, 10.07.78.
Derwent Abstract 81996a/45, U.S. Pat. No. 4,123,463, 21.03.78.
Derwent Abstract 20192c/11, U.S. Pat. No. 4,191,837, 05.04.78.

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