9-Deoxy-9-methylene-16-phenyl-PGF compounds

Details 9-Deoxy-9-methylene-16-phenyl-PGF compounds 9-Deoxy-9-methylene-16-phenyl-PGF compounds

1977-04-11

1978-10-03

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562465, C07C17700

Patent

active

041185846

ABSTRACT:
The present invention relates in part to novel amido, cycloamido, carbonylamido and sulfonylamido derivatives and p-substituted phenyl esters of 9-deoxy-9-methylene-PGF-type compounds. These novel amides produce surprisingly prolonged oral activity as pharmacological agents, as compared to the previously known 9-deoxy-9-methylene-PGF-type compounds.
Further, the novel p-substituted phenyl esters provide more stable pharmaceutical formulations as compared to known 9-deoxy-9-methylene-PGF-type esters.
Additionally, a novel series of 16-phenyl-9-deoxy-9-methylene-PGF-type compounds in free acid, ester, C-1 alcohol, and C-1 amine form is provided. Such compounds exhibit characteristic prostaglandin-type pharmacological actions.

REFERENCES:
patent: 3931299 (1976-01-01), Strike

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