9-Deoxy-9.alpha.,6-nitrilo or 6,9.alpha.-imino-PGF compounds

Details 9-Deoxy-9.alpha.,6-nitrilo or 6,9.alpha.-imino-PGF compounds 9-Deoxy-9.alpha.,6-nitrilo or 6,9.alpha.-imino-PGF compounds

1977-06-17

1978-06-27

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029356, 26029361, 260295F, 260295K, 26037625, 42424854, 42424855, 424250, 424263, 424267, 424274, 544143, 544144, 544362, 544373, 544364, 542426, 542429, 542430, 542431, C07D20952

Patent

active

040974898

ABSTRACT:
This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) wherein a nitrogen atom is substituted for the 6,9.alpha.-epoxy-oxygen of prostacyclin. These novel nitrogen-containing prostacyclin-type compounds are useful for the pharmacological purposes for which prostacyclin is used, e.g., as antithrombotic agents, smooth muscle stimulators, gastric antisecretory agents, antihypertensive agents, antiasthma agents, nasal decongestants, or regulators of fertility and procreation.

REFERENCES:
patent: 3931289 (1976-01-01), Bundy
patent: 3983157 (1976-09-01), Bundy
patent: 3983158 (1976-09-01), Bundy
Johnson et al., Prostaglandins, vol. 12, p. 915 (1976).

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