9-deazaguanines

Details 9-deazaguanines 9-deazaguanines

1990-10-31

1992-03-31

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544320, 544321, 544280, C07D23936, C07D23947, C07D48704

Patent

active

051010305

ABSTRACT:
The present invention is novel derivatives of pyrrolo [3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.

REFERENCES:
Modern Synthetic Reactions, 2nd Ed. (1972), pp. 4,8 and 9, Benjamin/Cummings Publ. Co., Menlo Park, Calif.

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