9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated f

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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4352571, 435946, 536 168, 536 174, C12N 112, C12P 1960

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active

056838956

ABSTRACT:
The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of ##STR1##

REFERENCES:
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J. Gilbert, Ecology, 71, 1727-1740 (1990)--culture strain sample received from Dr. Gilbert of Dartmouth College.
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