9-Cyclohexyl-2-alkoxy-9H-adenine process

Details 9-Cyclohexyl-2-alkoxy-9H-adenine process 9-Cyclohexyl-2-alkoxy-9H-adenine process

1980-02-25

1981-08-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

424253, 424251, 544254, 544315, C07D47318

Patent

active

042860938

ABSTRACT:
A process for preparing 9-cyclohexyl-2-alkoxy-9H-adenine derivatives such as 9-cyclohexyl-2-n-propoxy-9H-adenine from 7-amino-5-(methylthio)[1,2,5]oxadiazolo[3,4-d]pyrimidine and 7-amino-5-(methylthio)[1,2,5]thiadiazolo[3,4-d]pyrimidine is described. Other aspects of the invention are directed to novel intermediates such as the compound 4-amino-6-(cyclohexylamino)-5-(formylamino)-2-(methylthio)pyrimidine.

REFERENCES:
patent: 3857842 (1974-12-01), Asai
patent: 3884827 (1975-05-01), Asai
patent: 4172829 (1979-10-01), Naito et al.
Taylor et al., J. Org. Chem. 36(21), 3211, (1971).
Hartman et al., J. Org. Chem. 43(5), 960, (1978).

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