9.beta.-D-Arabinofuranosylpurine nucleotides and method of use

Details 9.beta.-D-Arabinofuranosylpurine nucleotides and method of use 9.beta.-D-Arabinofuranosylpurine nucleotides and method of use

1974-03-15

1978-06-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 27, 536 28, 536 29, A61K 3152, C07H 1920, A61K 3170

Patent

active

040937143

ABSTRACT:
9-.beta.-D-Arabinofuranosyl nucleotides of the following structure are disclosed: ##STR1## wherein AP is a 3' or 5' phosphorylated arabinofuranoside or the corresponding 3', 5' cyclic phosphate joined by a glycoside linkage to N.sup.9 of the aglycon component of said nucleotide, and Z is H, C.sub.1 -C.sub.6 alkyl, C.sub.7 -C.sub.10 aralkoxy, or hydroxy.
Compounds prepared according to the invention exhibit antiviral activity in vitro, while others are precursors useful in the synthesis of bioactive compounds.

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patent: 3328389 (1967-06-01), Shimizu et al.
patent: 3337530 (1967-08-01), Hanze
patent: 3728329 (1973-04-01), Yano et al.
patent: 3755296 (1973-08-01), Kanai et al.

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