9-Aryloxy prostane derivatives

Details 9-Aryloxy prostane derivatives 9-Aryloxy prostane derivatives

1979-09-26

1982-07-06

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

562465, 562471, 2605011, 562470, 564 52, 26050113, 564169, 564189, 26050115, 568 31, 568 32, 544235, 568630, 568632, 544283, 568634, 568656, 544349, 424251, 424256, 544356, 424258, 424269, 546339, 424274, 424286, 546341, 424308, 424309, 546344, 548460, 548454, 546176, 549407, 549435, 548250, 549437, 549466, 548253, 548484, 548486, 549 49, 549 58, 549355, 549399, 560 21, 560 24, 560 32, 560 55, 560 60, 560106, 560111, 560115, 560162, 562434, 562438, 562452, 562455, C07C17700, A61K 31557

Patent

active

043383165

ABSTRACT:
The disclosure relates to 9.beta.-aryloxy prostane derivatives, for example 16-(3-chlorophenoxy)-11.alpha.,15.alpha.-dihydroxy-16-methyl-9.beta.-pheno xy-18,19,20-trinor-5-cis,13-trans-prostadienoic acid, which possess high activity as abortifacients, cervical softeners, inducers of parturition or inhibitors of gastric acid production in mammals. These properties are typical of prostaglandin analogues of the E series, but chemically the new 9.beta.-aryloxy prostane derivatives are prostaglandin F series analogues and are therefore more stable than the E series analogues previously used for the above purposes. The new derivatives are manufactured by known analogy processes, and are formulated in conventional manner.

REFERENCES:
Derwent Abstract 43880v/24, DT 2259-260, 6/6/74.

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