9-amino-podophyllotoxin derivatives, method for the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S423000, C548S526000

Reexamination Certificate

active

07378419

ABSTRACT:
The invention relates to compounds of formula (I), wherein R1is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof

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Cho et al. J. Med. Chem., 1996, 36, 1383-1395.
Carmichael et al.; “Evaluation of a Tetrazolium-Based Semiautomated Colorimetric Assay: Assessment of Chemosensitivity Testing”; Cancer Research, vol. 47, pp. 936-942, Feb. 15, 1987.
Cho et al.; “Antitumor Agents. 163. Three-Dimensional Quantitative Structure-Activity Relationship Study of 4′-O-Demethylepipodophyllotoxin Analogs Using the Modified CoMFA/q2-GRS Approach”; J. Med. Chem. vol. 39, pp. 1383-1395, (1996).

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