9-amino-acridine derivatives and their use for eliminating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S297000, C514S253030, C540S586000, C540S587000, C544S361000

Reexamination Certificate

active

07951796

ABSTRACT:
The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating diseases associated with misfolded proteins.

REFERENCES:
patent: 2004/0229898 (2004-11-01), Prusiner et al.
patent: 02/096431 (2002-12-01), None
patent: 03/059885 (2003-07-01), None
patent: 2004/032929 (2004-04-01), None
patent: 2004/092170 (2004-10-01), None
May, Barnaby C.H. et al.; “Potent inhibition of scrapie prion replication in cultured cells by bis-aridines”; Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, DC, US; vol. 100, No. 6; Mar. 18, 2003, pp. 3416-3421, XP002386930.
Kocisko, David A. et al.; “New inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products”; Journal of Virology; The American Society for Microbiology, US; vol. 77, No. 19; Oct. 2003; pp. 10288-10294; XP008053706.
Korth, Carsten et al.; “Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease”; Proceedings of the National Academy of Sciences of USA; National Academy of Science, Washington, DC, US; vol. 98, No. 17; Aug. 14, 2001; pp. 9836-9841; XP002237386.
Prusiner, Stanley B. et al.; “Therapeutic Approaches to Prion Diseases”; Cold Spring Harbor Monograph Series; Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, US; 2004; pp. 961-1014; XP009065375.
Bosque, Patrick J. et al.; “Cultured Cell Sublines Highly Susceptible to Prion Infection”; Journal of Virology; May 2000; pp. 4377-4386; vol. 74, No. 9.
Fischer, Marek et al.; “Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie”; The EMBO Journal; vol. 15, No. 6; pp. 1255-1264; 1996.
Chandler, R.L, “Encephalopathy in Mice Produced by Inoculation With Scrapie Brain Material”; Lancet; Jun. 24, 1961; 1(7191): 1378-9.

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