9-Amino-3,4-dihydroacridines and related compounds useful for en

Details 9-Amino-3,4-dihydroacridines and related compounds useful for en 9-Amino-3,4-dihydroacridines and related compounds useful for en

1987-01-28

1989-06-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514297, 546 79, 546 93, 546105, 546106, A61K 3147, C07D21910

Patent

active

048393649

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.Ch where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

REFERENCES:
patent: 3033866 (1962-05-01), Saggiomo et al.
patent: 3122553 (1964-02-01), Seneca
patent: 3232945 (1966-02-01), Sigal, Jr. et al.
patent: 3318896 (1967-05-01), Pribyl et al.
patent: 3947449 (1976-03-01), Durckheimer et al.
patent: 4284627 (1981-08-01), Raether et al.
patent: 4550113 (1985-10-01), Lavretskaya et al.
patent: 4631286 (1986-12-01), Shutske et al.
patent: 4695573 (1987-09-01), Shutske et al.
Albert, "The Acridines", 2nd ed., St. Martin's Press, New York 1966, pp. 45-47.
Magidson et al., Chemical Abstracts, vol. 31, 58007 (1937).
Sargent et al., J. Org. Chem., vol. 11, pp. 350-362 (1946).
Sargent et al., J. Org. Chem., vol. 12, pp. 567-570 (1947).
Sargent et al., J. Org. Chem., vol. 12, pp. 571-576 (1947).
Stephen et al., J. Chem. Soc., (1947), pp. 1034-1039.
Desai et al., J. Indian Chem. Soc., vol. 37, No. 9, pp. 553-556 (1960).
Steinberg et al., J. Med. Chem., vol. 18, No. 11, pp. 1056-1061 (1975).
Brian et al., Chemical Abstracts, vol. 62, 6459e (1965).
Albert, The Acridines, 2nd ed., St. Martin's Press, N.Y. (1966), pp. 431-432.
Patnaik et al., J. Med. Chem., vol. 9, pp. 483-488 (1966).
Konshin et al., Chemical Abstracts, vol. 76, 34080k (1972).
Konshin et al. (T'), Chemical Abstracts, vol. 81, 120411d (1974).
Koupilova et al., Chemical Abstracts, vol. 96, 155388p (1982).
Brian et al. (II), J. Med. Chem., vol. 8, pp. 143-144 (1965).
Konshin et al., Khim-Farm. Zh., vol. 5, No. 11, pp. 10-12 (1971).
Davies, Drug Development Research, vol. 5, pp. 69-76 (1985).
Johns et al., Drug Development Research, vol. 5, pp. 77-96 (1985).
Ellman et al., Biochemical Pharmacology, vol. 7, pp. 88-95 (1961).
Schindler et al., Drug Development Research, vol. 4, pp. 567-576 (1984).
Bartus et al., Science, vol. 209, pp. 301-303 (07/11/80).
Broekkamp et al., Psychopharmacology, vol. 83, pp. 122-125 (1984).
Komiskey et al., Psychopharmacology, vol. 73, pp. 304-305 (1981).

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