9-amino-2-phenylbicyclo[3.3.1]nonanes and 9-amino-2-phenylbicycl

Details 9-amino-2-phenylbicyclo[3.3.1]nonanes and 9-amino-2-phenylbicycl 9-amino-2-phenylbicyclo[3.3.1]nonanes and 9-amino-2-phenylbicycl

1991-06-11

1992-10-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514 83, 514240, 514212, 514319, 514408, 540450, 540484, 540611, 548400, 548577, 548950, 546205, 564308, A61K 31445, A61K 31135, C07C21100, C07D21126

Patent

active

051532280

ABSTRACT:
9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R.sup.3 and R.sup.4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R.sup.3 and R.sup.4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.

REFERENCES:
patent: 3164601 (1965-01-01), Thesing et al.
patent: 3742055 (1973-06-01), Freedman
Journal of the American Chemical Society, vol. 72, No. 8, Aug. 15, 1950, pp. 3405-3410, A. C. Cope, et al., "Cyclic Polyolefins. X. Synthesis of Phenylcycloocta-1,3-diene.sup.1 ".
Journal of the Chemical Society, vol. 16, 1968, pp. 2032-2039, R. A. Appleton, et al., "Studies on Bicyclononanes. Part V.1 Formation of Substituted Bicyclononanes from Enamines".
Journal of the American Chemical Society, vol. 96, No. 1, Jan. 9, 1974, pp. 149-154, H. Caldararu, et al., "Electron Spin Resonance Study of Some Iminoxy Radicals. Stereochemistry of Bicyclic Systems".

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