9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives the

Details 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives the 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives the

1981-08-27

1982-09-28

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424854, 42424855, 424250, 424258, 544126, 544361, 546108, C07D22112

Patent

active

043518338

ABSTRACT:
9-Amino-1-hydroxyoctahydrobenzo[c]quinoline derivatives of formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R is hydrogen, COR.sub.7 or SO.sub.2 R.sub.8 where R.sub.7 is hydrogen, alkyl, having from one to five carbon atoms; alkenyl and alkynyl each having from two to six carbon atoms; trifluoromethyl, benzyl, furyl, thienyl, pyridyl or R.sub.9 C.sub.6 H.sub.4 where R.sub.9 is H, NH.sub.2, F, Cl, Br, Ch.sub.3 or OCH.sub.3 ; R.sub.8 is alkyl having from one to five carbon atoms or R.sub.9 C.sub.6 H.sub.4 ; R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl having from one to five carbon atoms or --CO--(CH.sub.2).sub.p --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4; each of R.sub.2 and R.sub.3 when taken individually is hydrogen or alkyl having from one to four carbon atoms; R.sub.2 and R.sub.3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrrolo, pyrrolidino, morpholino or N-alkylpiperazino having from one to four carbon atoms in the alkyl group;

REFERENCES:
patent: 3878219 (1975-04-01), Lee
patent: 3928598 (1975-12-01), Archer
patent: 4087545 (1978-05-01), Archer et al.
patent: 4152450 (1979-05-01), Day et al.
Hardman et al., Proc. West. Pharmacol. Soc., 14, 14-20, (1971).
Mechoulam and Edery in "Marijuana", edited by Mechoulam, Academic Press, New York, 1973, p. 127.
Paton, in Ann. Rev. Pharmacol., 15, 192, (1975).
Beil, in "Psychotomimetic Drugs", Efron, Ed., Raven Press, New York, 1970, p. 336.
Sallan et al., New England J. Med., 293, 795, (1975).
Borison et al., New England J. Med., 298, 1480, (1978).

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