9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds

Details 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds

1987-11-25

1988-06-28

Brust, Joseph P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12152

Patent

active

047540508

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

REFERENCES:
Albert, "The Acridines", 2nd Ed., (1966), pp. 34 to 36 and 51; St. Martin's Press, N.Y.

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