9.alpha., 11.beta.-substituted and 11.beta.-substituted estranes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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Details

26039745, 2603975, 514179, 514182, A61K 3156, C07J 0000

Patent

active

047057831

ABSTRACT:
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.

REFERENCES:
patent: 3755574 (1973-08-01), Bertin et al.
patent: 3980681 (1976-09-01), Sykes et al.
patent: 4312864 (1982-01-01), Tax
Chemical Abstracts; vol. 75 (1971) #129995F; Sykes et al.
Chemical Abstracts; vol. 75 (1971) #88842H; Sykes et al.
Tetrahedron Letters, P. J. Sykes, "Oxidation Of Ring A-Aromatic Steroids To 9,11/3-Diol 11-Nitrates With Ceric Ammonium Nitrate" No. 37, Sep. 1971, pp. 3393-3395.
Steroids, vol. 34, No. 4. Oct. 1979, J. Salmon et al., "Reference Compounds For The Study Of Moxestrol Metabolism" pp. 381-400.
Chemical Abstracts, vol. 100, No. 15, Apr. 1984, Li, Zhensu et al., "Synthesis of 11-Substituted (Containing Oxygen Group) Estradiol), p. 626, Abstract No. 121429p.
Journal of Medicinal Chemistry, vol. 10, No. 6, Nov. 1967, J. S. Baran, "A Synthesis Of 11beta-Hydroxyestrone And Related 16-and 17-Hydroxyestratrienes", pp. 1188-1190.
J. P. Raynaud, et al.; Drug Design, vol. VIII, 1979, pp. 178-181.

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