9 alpha, 11 beta-substituted and 11 beta-substituted estranes

Details 9 alpha, 11 beta-substituted and 11 beta-substituted estranes 9 alpha, 11 beta-substituted and 11 beta-substituted estranes

1989-11-09

1992-12-01

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 552506, 552508, A61K 3156, C07J 5300

Patent

active

RE0341363

ABSTRACT:
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.

REFERENCES:
patent: 3755574 (1973-08-01), Bertin et al.
patent: 3980681 (1976-09-01), Sykes et al.
patent: 4312864 (1982-01-01), Tax
Chemical Abstracts, vol. 75 (1971) #88842H, Sykes et al.
Tetrahedron Letters, No. 37, pp. 3393-3396 (1971), Sykes et al.
Chemical Abstracts, vol. 75 (1971) #129995F, Sykes et al.
Steroids, vol. 34, No. 4, Oct. 1979, J. Salmon et al., "Reference Compounds For The Study of Moxestrol Metabolism" pp. 381-300.
Chemical Abstracts, vol. 100, No. 15, Apr. 1984, Li, Zhensu et al., "Synthesis of 11-Substituted (Containing Oxygen Group) Estradiol)," p. 626, Abstract No. 121429p.
Journal of Medicinal Chemistry, vol. 10, No. 6, Nov. 1967, J. S. Baran, "A Synthesis Of 11beta-Hydroxyestrone And Related 16-and 17-Hydroxyestratrienes", pp. 1188-1190.
J. P. Raynaud, et al.; Drug Design, vol. VIII, 1979, pp. 178-181.

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