9-(3 cyanophenyl) hexahydro-1,8 acridinedione

Details 9-(3 cyanophenyl) hexahydro-1,8 acridinedione 9-(3 cyanophenyl) hexahydro-1,8 acridinedione

1992-10-20

1993-11-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546103, C07D21908

Patent

active

052583902

ABSTRACT:
The invention provides the novel compound, 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridinedione and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing the compound, and the use of the compound in the treatment of urinary incontinence.

REFERENCES:
patent: 3454577 (1969-07-01), Lehr et al.
patent: 3901710 (1975-08-01), Ranz et al.
patent: 4021434 (1977-05-01), Murakami
patent: 4546186 (1985-10-01), Abou-Gharbia
S. M. Jain, et al. "Synthesis and Pharmacological screening of 1,8-dioxo-9-(substituted phenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridines" Ind. J. Chem. (1991), 30B, 1037-1040.
H. Antaki "The Synthesis of Ethyl 4-Aryl-5,6,7,8-tetrahydro-5-oxo-quinoline-3-carboxylates and their Derivatives" J. Chem. Soc. (1963), 4877-4879.
Ibrahim Chaaban, et al. "Enaminones in the Mannich Reaction. Part 2. Further Investigations of Internal Mannich Reactions" J. Chem. Soc., Perkin I (1979), 1593-1596.
Magid Abou-Gharbiz "Synthesis of Novel Hexahydroquinolines and Hexahydroactridines" Heterocycles (1986), 5, 1347-1353.

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