9,11-Methano-13-aza-11a-carbathrombanoic acid analogues

Details 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues

1981-07-22

1983-06-21

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260404, 424309, 424319, 560 9, 560 18, 560 45, 560 48, 560116, 560118, 562427, 562452, 562457, 562498, 562500, A61K 31557, C07C10114

Patent

active

043894135

ABSTRACT:
The 9,11-methano-13-aza-11a-carbathrombanoic acid analogues of the general formula: ##STR1## [wherein A represents ##STR2## (in which m is an integer of 1 to 6, the double bond between the carbon atoms in positions 5 and 6 in (iv) is in cis or trans-configuration or a mixture thereof and the phenylene group in (iv) represents o-, m- or p-phenylene), R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group of 1 to 12 carbon atoms, two R.sup.2 both represent hydrogen atoms or methyl groups, R.sup.3 represents a hydrogen atom or a hydroxy group, R.sup.4 represents a single bond or a straight- or branched-chain alkylene group of 1 to 5 carbon atoms, R.sup.5 represents

REFERENCES:
patent: 4182903 (1980-01-01), Favara et al.
patent: 4188403 (1980-02-01), Orth et al.
patent: 4239778 (1980-12-01), Venton et al.
patent: 4260806 (1981-04-01), Nicolaou et al.
Fried et al., Advances in Prostaglandin & Thromboxane Research, vol. 6, p. 427 (1980).

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