9,10-Secoestrane derivatives and their production

Details 9,10-Secoestrane derivatives and their production 9,10-Secoestrane derivatives and their production

1975-04-21

1977-03-15

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603409, C07D31746, C07D31908

Patent

active

040124207

ABSTRACT:
9,10-Secoestranes, useful as intermediates in the total synthesis of steroids, of the formula ##STR1## WHEREIN N IS 1 OR 2, R.sub.1 is lower alkyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkoxy or acyloxy, X is free or ketalized carbonyl or free, esterified or etherified hydroxymethylene, and Y is carbonyl or dialkoxymethylene are produced by condensing, in the presence of a basic catalyst, ##STR2## WHEREIN X, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4 have the values given above, and Z is Cl, Br or I, to produce a 9,10-secoestrane of the above formula wherein Y is a free carbonyl group, which can then, if desired, be ketalized to a corresponding compound wherein Y is dialkoxymethylene or like ketal group.

REFERENCES:
patent: 3637754 (1972-01-01), Bucourt et al.
patent: 3647821 (1972-03-01), Los

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