80090, human fucosyltransferase nucleic acid molecules and...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S069100, C435S252300, C435S320100, C536S023100, C536S023200, C530S350000

Reexamination Certificate

active

06979564

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, which encode novel fucosyltransferase, seven transmembrane receptor, or RhoGAP family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an 80090, 52874, 52880, 63497, or 33425 gene has been introduced or disrupted. The invention still further provides isolated 80090, 52874, 52880, 63497, or 33425 proteins, fusion proteins, antigenic peptides and anti-80090, 52874, 52880, 63497, or 33425 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
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patent: 2003/0165831 (2003-09-01), Lee et al.
patent: 1 394 274 (2004-03-01), None
patent: WO/0142451 (2001-06-01), None
patent: WO 03/029271 (2003-04-01), None
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Martinez-Duncker, I. et al., “Homo sapiensmRNA for alpha3-fucosyltransferase (FUT10 gene)”, Sep. 4, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. AJ582015.
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Candelier, J. J., et al., “Homo sapiensmRNA for Putative alpha 1,3-fucosyltransferase (FUT10 gene)”, Jan. 2, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. AJ512465.
Candelier, J. J., et al., “Homo sapiensmRNA for Putative alpha3-fucosyltransferase (FUT10 gene)”, Feb. 1, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jul. 19, 2004]. GenBank Accession No. AJ35838.
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Strausberg, R. L., et al., “FUT10 protein [Homo sapiens]”, Dec. 23, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. AAH63462.
Martinez-Duncker, I. et al., “alpha3-fucosyltransferase [Homo sapiens].”, Sep. 4, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. CAE46499.
Roos, C., et al., “Putative alpha 1,3-fucosyl transferase [Homo sapiens]”, Feb. 26, 2002 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. CAD24023.
Candelier, J. J., et al., “Putative alpha 1,3-fucosyltransferase [Homo sapiens]”, Jan. 2, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information GenBank Accession No. CAD54669.
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Musacchio et al. “Crystal Structure of the Breakpoint Cluster Region-Homology Domain from Phosphoinositide 3-Kinase p85 α Subunit” Proc. Natl. Acad. Sci. USA 93:14373-14378 (1996).
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Blast search for 33425 in dbEST database.
Blast search for 33425 in FastAlert_N.txt database.
Blast search for 33425 in FastAlert_P.txt database.
Blast search for 33425 in nuc database.
Blast search for 33425 in PATENT_2/gsnuc database.
Blast search for 33425 in protot database.
Blast search for 33425 in PATENT_2/gsprot database.
Blast search for 52874aa in FastAlert_P.txt database.
Blast search for 52874aa in protot database.
Blast search for 52874aa in PATENT_2/gsprot database.
Blast search for 52874nc in FastAlert_N.txt database.
Blast search for 52874nc in nuc database.
Blast search for 52880 in FastAlert_N.txt database.
Blast search for 52880 in MGP_human_gb.fasta database.
Blast search for 52880 in gsnuc database.
Blast search for 52880 in nuc database.
Blast search for 52880 in FastAlert_P.txt database.
Blast search for 52880 in protot database.
Blast search for 52880 in gsprot database.
Blast search for 52880 in PatentDbPreviewNuc database.
Blast search for 63497 in FastAlert_P.txt database.
Blast search for 63497 in nuc database.
Blast search for 63497 in FastAlert_N.txt database.
Blast search for 63497 in MGP_human_gb.fasta database.
Blast search for 63497 in gsnuc database.
Blast search for 63497 in protot database.
Blast search for 63497 in gsprot database.
Blast search for 63497 in PatentDbPreviewNuc database.
Blast search for 80090aa in FastAlert_P.txt database.
Blast search for 80090aa in protot database.
Blast search for 80090aa in PATENT_2/gsprot database.
Blast search for 80090nc in FastAlert_N.txt database.
Blast search for 80090nc in nuc database.
Blast sea

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