Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2008-05-20
2008-05-20
Badio, Barbara P. (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C514S176000, C552S626000, C552S629000
Reexamination Certificate
active
07375098
ABSTRACT:
This invention relates to 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes of general formula Iwith ERβ-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparations that contain the compounds according to the invention, as well as their use for the production of pharmaceutical agents.The new compounds can be used for contraception in men and women without influencing other estrogen-sensitive organs such as the uterus or the liver.They are also suitable for treating benign or malignant proliferative diseases of the ovary, such as ovarian cancer and granulosa cell tumors.
REFERENCES:
patent: 10151114 (2003-04-01), None
patent: WO01/77138 (2001-10-01), None
Lobaccaro C et al: “Steroidal Affinity Labels of the Estrogen Receptor 3, Estradiol 11.beta.-n-Alkyl Derivatives Bearing a Terminal Electrophilic Group: Anti-Estrogenic and Cytotoxic Properties” Journal of Medicinal Chemistry, American Chemical Society, Washington US, bd. 40, Nr. 14, Jul. 4, 1997.
Bohlmann Rolf
Braeuer Nico
Hillisch Alexander
Muhn Hans-Peter
Peters Olaf
Badio Barbara P.
Millen White Zelano & Branigan P.C.
Schering A.G.
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