8-tricycloalkyl xanthine derivatives

Details 8-tricycloalkyl xanthine derivatives 8-tricycloalkyl xanthine derivatives

1994-04-05

1995-03-07

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544273, 514869, C07D47304, C07D47306, A61K 3152

Patent

active

053958365

ABSTRACT:
There is provided a novel xanthine Compound(I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is ##STR2## wherein R.sup.3 and R.sup.4 are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R.sup.3 and R.sup.4 are hydrogen, at least one of R.sup.1 and R.sup.2 is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof.
The xanthine compound has adenosine A.sub.1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.

REFERENCES:
patent: 4233303 (1980-11-01), Bergstrand et al.
patent: 4755517 (1988-07-01), Bruns et al.
patent: 5290782 (1994-03-01), Suzuki et al.
patent: 5342841 (1994-08-01), Suzuki
Patent Abstracts of Japan, vol. 17, No. 63 (Feb. 8, 1993) (C-1024), for JP 4-270222.
Henin et al., Tetrahedron Letters, vol. 27, No. 52 (1986) 6339-40.

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